In 2017, AO2 Clear's Chief Scientist, Dr. Zvi Yaniv, Ph.D., took to his lab to develop a gentler and more effective treatment for peripheral neuropathy in his hands and feet. A prolific, globally-recognized inventor with over 300 nanotechnology patents Dr. Yaniv harnesses the power of oxygen and nanobubbles to deliver unprecedented relief directly to the source of his pain—oxygen-starved nerves beneath the skin.

Dr. Zvi Yaniv teamed up with board-certified dermatologist, Dr. Valerie Hanft, Ph.D., who revealed that pure oxygen has a remarkable clearing effect on acne by killing the anaerobic bacteria that cause acne inflammation inside our pores. Dr. Hanft was inspired by the prospect of offering her patients a less irritating but just as effective acne treatment. Together they set to work testing formulations of oxygen nanobubbles in different topical applications and created AO2 Clear.

AO2 Clear is the only topical acne treatment that contains just oxygen and distilled water. AO2 Clear combines the potent antibacterial properties of oxygen with the radical power of nanobubbles to get deep into individual pores and target the bacteria that cause acne.